Citrate of protein kinase inhibitor as well as crystal form, preparation method and application thereof

• Main Authors: HUANG RONGTAO, HUANG WENSHU, JIN MEIXIA, ZHU SHUANG, WANG KEXIN, PENG YUHUI, ZHU QIAOYOU, YU JIANGTIAN, LIU JIUZHI
• Format: Patent
• Language: Chinese; English
• Published: 03.10.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to citrate of a compound of formula (I). The invention also relates to a crystal form A, a crystal form B, a crystal form C and a crystal form D of citrate of the compound shown in the formula (I). The invention also relates to a pharmaceutical composition which comprises citrate of the compound (I), and at least one of crystal form A, crystal form B, crystal form C and crystal form D. The invention further relates to application of the citrate, the crystal form A, the crystal form B, the crystal form C and the crystal form D of the citrate and the pharmaceutical composition in preparation of drugs for treating, preventing or improving abnormal cell proliferation. The invention also relates to application of the citrate, the crystal form A, the crystal form B, the crystal form C and the crystal form D of the citrate and the pharmaceutical composition of the invention, optionally combined with a second therapeutic agent, in preparation of drugs for treating, preventing or improving abnorm