Application of A beta1-42 in preparation of preeclampsia treatment medicine or diagnostic kit

• Main Authors: LIU WEI, CHENG KAI, GAO QIAN, CAI LEIMING, NIE ZHIWEN, LI QIAN
• Format: Patent
• Language: Chinese; English
• Published: 03.10.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention relates to the technical field of biomedical engineering, discloses application of an A beta 1-42 inhibitor in preparation of an anti-preeclampsia drug, an A beta 1-42 inhibitor recombinant vector and application of the A beta 1-42 inhibitor recombinant vector in preparation of the anti-preeclampsia drug, and further provides application of a reagent for detecting the content of A beta 1-42 in preparation of a preeclampsia diagnostic kit. The invention further provides an anti-eclampsia pharmaceutical composition and a pre-eclampsia diagnosis kit. Based on the research on PE placenta and TM stimulated HTR-8/SVneo cells, the expression of A beta 1-42 in the samples is relatively high. Therefore, the accuracy and sensitivity of the PE can be improved by detecting the level of Abeta1-42, and a better scheme is provided for treatment and management of the PE. 本发明涉及生物医药工程技术领域，Aβ1-42抑制剂在制备抗子痫前期药物中的用途、Aβ1-42抑制剂重组载体及其在制备抗子痫前期药物中的用途，还提供了检测Aβ1-42含量的试剂在制备子痫前期诊断试剂盒中的用途，并进一步提供了抗子痫药物组合物和子痫前期诊断试剂盒。本发明基于对PE胎盘和被