Azaquinazoline pan KRas inhibitors

The present invention relates to compounds that inhibit at least one of KRas G12A, KRas G12C, KRas G12D, KRas G12R, KRas G12S, KRas G12V, KRas G13D, and KRas Q61H, pharmaceutical compositions comprising the compounds, and methods of use thereof. 本发明涉及抑制KRas G12A、KRas G12C、KRas G12D、KRas G12R、KRas G1...

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Bibliographic Details
Main Authors SMITH CHRISTOPHER RONALD, MARX MATTHEW ARNOLD, LAWSON JOHN DAVID, KULUK SVITLANA, WANG XIAOLUN
Format Patent
LanguageChinese
English
Published 29.09.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compounds that inhibit at least one of KRas G12A, KRas G12C, KRas G12D, KRas G12R, KRas G12S, KRas G12V, KRas G13D, and KRas Q61H, pharmaceutical compositions comprising the compounds, and methods of use thereof. 本发明涉及抑制KRas G12A、KRas G12C、KRas G12D、KRas G12R、KRas G12S、KRas G12V、KRas G13D和KRas Q61H中的至少一者的化合物、包含所述化合物的药物组合物及其使用方法。
Bibliography:Application Number: CN202180093775