Nucleic acid sulfide compound and preparation process thereof

• Main Authors: GAO EN, LIU ZONGWEN, LIU QI, SHEN CHENGXIANG, YONG JINGUI
• Format: Patent
• Language: Chinese; English
• Published: 29.09.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a nucleic acid sulfide compound and a preparation process thereof, and belongs to the technical field of nucleic acid medicines. According to the invention, bovine serum albumin (BSA) is used as an accelerant to synthesize BSA-CuS nanoparticles, the BSA-CuS nanoparticles have a remarkable hollow mesoporous structure to realize drug loading, and then the nucleic acid sulfide compound (siRNA-BSA-CuS) is prepared by using a desolventizing-crosslinking method. BSA serves as a medium to synthesize a nucleic acid sulfide compound, not only serves as an accelerant to promote the CuS nanoparticles to form a hollow mesoporous structure, but also serves as a sealing agent to seal siRNA, so that the siRNA is not decomposed in the carrying process, and targeted drug delivery is achieved. The nucleic acid sulfide compound prepared by the invention has remarkable photo-thermal sensitivity and strong drug loading performance, and has important application prospects in tumor photo-thermal therapy. 本发明