Tanshinone IIA derivative and application thereof

The invention discloses a tanshinone IIA derivative and application thereof, and belongs to the technical field of pharmacy. The invention provides a compound as shown in a formula (I) or a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a pharmaceutically accep...

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Main Authors CUI SUNLIANG, HIRABUCHI, FAN CHENGCHENG, WAN KANGLIN, WANG RUIBAI, ZHOU CHANGXIN, WANG ZHENZHEN
Format Patent
LanguageChinese
English
Published 26.09.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:The invention discloses a tanshinone IIA derivative and application thereof, and belongs to the technical field of pharmacy. The invention provides a compound as shown in a formula (I) or a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a pharmaceutically acceptable salt or a prodrug thereof. Mannich reaction is taken as a key synthesis step, framework transition of the tanshinone IIA is realized, a piperidine ring and a side chain are merged into a D ring (furan ring) of the tanshinone IIA, and compared with the tanshinone IIA, the compound disclosed by the invention can realize a remarkable antibacterial effect on fully-sensitive mycobacterium tuberculosis and widely-drug-resistant mycobacterium tuberculosis. # imgabs0 # 本发明公开了一种丹参酮ⅡA衍生物及其应用，属于制药技术领域。本发明提供一种式(I)所示的化合物或其立体异构体、几何异构体、互变异构体、氮氧化物、水合物、溶剂化物、药学上可接受的盐或前药。以曼尼希反应作为关键合成步骤，实现丹参酮IIA的骨架跃迁，在丹参酮IIA的D环(呋喃环)上并入哌啶环及侧链，和丹参酮IIA相比，本发明化合物对于全敏感型结核分枝杆菌和广泛耐药型结核分枝杆菌均能实现显著的抗菌作用。#imgabs0#
Bibliography:Application Number: CN202210271652