Organic metal ruthenium macrocyclic complex as well as preparation method and application thereof

• Main Authors: FAN YIFAN, BAI SUYA, XU YULING, LI CHONGLU, MA XIN, SUN YAO
• Format: Patent
• Language: Chinese; English
• Published: 22.09.2023
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; ADHESIVES; CHEMISTRY; DYES; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC CHEMISTRY; PAINTS; POLISHES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of biological medicine, and discloses an organic metal ruthenium macrocyclic complex as well as a preparation method and application thereof, and the complex has a structure as shown in a formula (I). Compared with other commercialized chemotherapeutic drugs, the complex provided by the invention not only has good phototherapy-chemotherapy combined treatment capability, but also has smaller toxic and side effects and stronger anti-cancer effect; and the macrocyclic complex can realize tumor combined treatment precisely guided by a near-infrared two-region fluorescence imaging technology, so that the macrocyclic complex has great application potential in the field of biomedicine. # imgabs0 # 本发明涉及生物医药领域，公开了一种有机金属钌大环配合物及其制备方法与应用，该配合物具有式(I)所示的结构。与其它商品化化疗药物相比，本发明提供的配合物不仅具有良好的光疗-化疗联合治疗的能力，而且也具有更小的毒副作用和更强的抗癌效果；并且该大环配合物能够实现近红外二区荧光成像技术精准引导的肿瘤联合治疗，因此在生物医学领域方面具有很大的应用潜力。#imgabs0#