FXR regulator as well as preparation method and application thereof

The invention relates to the field of medicinal chemistry, in particular to an FXR regulator and a preparation method and application thereof. The structural general formula of the FXR regulator provided by the invention is # imgabs0, R1 is hydrogen, methyl, substituted phenyl or substituted amino,...

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Bibliographic Details
Main Authors CHU LIJUAN, BAI HAIFEN
Format Patent
LanguageChinese
English
Published 22.09.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to the field of medicinal chemistry, in particular to an FXR regulator and a preparation method and application thereof. The structural general formula of the FXR regulator provided by the invention is # imgabs0, R1 is hydrogen, methyl, substituted phenyl or substituted amino, R2 is hydrogen, carboxyl, carbamoyl, sulfonamide group, halogen, methyl, hydroxyl or cyano, and R2 can be singly substituted or polysubstituted on a benzene ring. The FXR regulator can be combined with an FXR receptor and is applied to preparation of drugs for preventing or treating metabolism-related diseases, cardiovascular diseases, liver diseases, cancers, nephropathy, bowel diseases, inflammation and other diseases. The invention also provides a preparation method of the FXR regulator. The preparation method has the advantages of easiness in operation, low cost of required raw materials and the like. 本发明涉及药物化学领域，具体涉及一种FXR调节剂及其制备方法与应用。本发明提供的FXR调节剂，其结构通式为#imgabs0#，R1为氢、甲基、取代的苯基或取代的氨基，R2为氢、羧基、氨基甲酰基、磺酰胺基团、卤素、甲基、羟基
Bibliography:Application Number: CN202310603973