Synthetic method of 3-chlorine substituted indole compound

• Main Authors: ZHANG CHEN, DU ZHAOLEI, SUN JIAWEI, ZHANG ZHENLIN, ZHANG ZHENBIN, SONG YANG
• Format: Patent
• Language: Chinese; English
• Published: 22.09.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a synthesis method of a 3-chlorine substituted indole compound, which comprises the following steps: dissolving an N, N-substituted o-alkynyl aniline derivative (structural formula II) in dimethyl sulfoxide, dropwise adding thionyl chloride under the condition of ice bath, a...