Synthetic method of 3-chlorine substituted indole compound

The invention relates to a synthesis method of a 3-chlorine substituted indole compound, which comprises the following steps: dissolving an N, N-substituted o-alkynyl aniline derivative (structural formula II) in dimethyl sulfoxide, dropwise adding thionyl chloride under the condition of ice bath, a...

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Bibliographic Details
Main Authors ZHANG CHEN, DU ZHAOLEI, SUN JIAWEI, ZHANG ZHENLIN, ZHANG ZHENBIN, SONG YANG
Format Patent
LanguageChinese
English
Published 22.09.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a synthesis method of a 3-chlorine substituted indole compound, which comprises the following steps: dissolving an N, N-substituted o-alkynyl aniline derivative (structural formula II) in dimethyl sulfoxide, dropwise adding thionyl chloride under the condition of ice bath, and reacting at 30-45 DEG C to obtain the 3-chlorine substituted indole compound (I), the reaction formula is as follows: # imgabs0 # R1, R2, R3 and R4 are mutually independent, and R1 is a hydrogen atom, a chlorine atom or a bromine atom; r2 is phenyl, substituted phenyl or thiophene; r3 is p-toluenesulfonyl or methylsulfonyl; and R4 is methyl or ethyl. The 3-chloroindole derivative is generated through the molecular internal cyclization reaction, and the method has the advantages of simple operation, cheap and easily available raw materials, mild reaction conditions, short reaction time, high yield, easy purification and the like. 本发明涉及一种3-氯取代的吲哚类化合物的合成方法，包括：将N,N-取代的邻炔基苯胺衍生物(结构式II)溶于二甲基亚砜中，在冰浴条件下逐滴加入二氯亚砜，于30-45℃进行
Bibliography:Application Number: CN202310755954