Product specifically aiming at immune cell activation/proliferation stimulation, preparation and application

• Main Authors: SHI XIAOJUAN, MIAO JINGYUN, SUN LIQIN, ZHOU ZELIN, CONG ZHENYU
• Format: Patent
• Language: Chinese; English
• Published: 22.09.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention relates to the technical field of biology, in particular to a product aiming at immune cell activation/proliferation stimulation and preparation and application thereof, the product can specifically stimulate immune cell proliferation and remarkably improve the positive rate of immune cells, and meanwhile compared with an activation mode directly based on tumor antigen in the prior art, the product has the advantages that the product is more stable and reliable. The tumor antigen and/or the activating antibody are/is coupled to carriers such as microspheres or magnetic beads, and the process that tumor cells of membrane expression target antigens deactivate CAR-T cells and stimulate the CAR-T cells to proliferate can be simulated. 本申请涉及生物技术领域，具体涉及一种针对免疫细胞激活/增殖刺激的产品、制备及其应用，所述产品能够特异性地刺激免疫细胞增殖，显著提高免疫细胞阳性率，同时，相比于现有技术中直接基于肿瘤抗原的激活方式，本申请肿瘤抗原和/或激活性抗体偶联在微球或磁珠等载体上，能够模拟膜表达靶抗原的肿瘤细胞去激活CAR-T细胞并刺激其增殖的过程。