ISR inhibitor as well as preparation method and application thereof

• Main Authors: ZHANG HUIBIN, ZHOU JINPEI, PEI YIFENG, WANG LIXUN
• Format: Patent
• Language: Chinese; English
• Published: 19.09.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an ISR inhibitor as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The compound provided by the invention is a compound with a structure as shown in a formula (I) or a formula (II), and a stereoisomer, a geometric isomer, a tautomer, a pharmaceutically acceptable salt, a prodrug, a hydrate or a solvate thereof, and # imgabs0. The compound provided by the invention can be effectively combined with eIF2B, has good ATF4 inhibition capability, and can be used for preparing a medicine for treating eIF2B. And the synthesis of protein can be well recovered during ISR stimulation. Therefore, the compound provided by the invention can be used as an ISR inhibitor and is used for treating various related diseases. 本发明公开了一类ISR抑制剂及其制备方法和应用，属于生物医药技术领域。本发明的化合物为具有式(I)或式(II)结构的化合物，其立体异构体、其几何异构体、其互变异构体、其药学上可接受的盐、其前药、其水合物或其溶剂化物，#imgabs0#本发明提供的化合物，能够与eIF2B有效结合，具有良好的ATF4抑制能力，在ISR刺激时能够较好的恢复蛋白质的合成。所以，本发明的化合物可作为ISR抑制剂并用于治疗各种相关病症。