Compound for targeted degradation of CD26 as well as preparation method and application of compound

The invention discloses a compound for targeted degradation of CD26 as well as a preparation method and application of the compound. The structures of the disclosed compounds are as shown in formulas (1)-(4). The targeted CD26 degradation product provided by the invention can provide a new scheme fo...

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Bibliographic Details
Main Authors ZHANG GUANGJIAN, LIU BOHAO, ZHU XINGZHUO, TAO RUNYI, GONG QIUYU
Format Patent
LanguageChinese
English
Published 19.09.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a compound for targeted degradation of CD26 as well as a preparation method and application of the compound. The structures of the disclosed compounds are as shown in formulas (1)-(4). The targeted CD26 degradation product provided by the invention can provide a new scheme for clinical individual or combined treatment of tumor patients with abnormal CD26 expression, and provides a new thought and prospect for treatment of cancers with abnormal CD26 expression. # imgabs0 # 本发明公开了一类靶向降解CD26的化合物、其制备方法与应用。所公开的化合物结构如式(1)～(4)所示。本发明的靶向CD26降解物可为临床上单独或联合治疗CD26异常表达肿瘤患者提供新的方案，为治疗CD26异常表达的癌症提供新的思路和前景。#imgabs0#
Bibliography:Application Number: CN202310660517