Method for preparing sulfonamide-containing heterocyclic acrylate from carbon dioxide

• Main Authors: SHA YU, YANG HAN, SUN SONG, YAO YANG, BAI JUNXUE
• Format: Patent
• Language: Chinese; English
• Published: 19.09.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to the fields of medicine, organic chemical industry and fine chemical industry, in particular to a method for preparing sulfonamide-containing heterocyclic acrylate from carbon dioxide. According to the method, o-alkynyl aryl sulfonamide is taken as a raw material, dry anhydrous dimethyl sulfoxide (DMSO) is taken as a solvent, reaction is carried out for 48 hours at room temperature under an alkaline condition, then methyl iodide is added, and reaction is carried out for 1 hour in an oil bath pan at the temperature of 50 DEG C to synthesize a product. A series of sulfonamide-containing heterocyclic acrylate can be obtained at medium to high yield through simple post-treatment in the reaction. The o-alkynyl sulfonamides of various substituent groups can be used as reaction substrates to obtain corresponding sulfonamide-containing heterocyclic acrylate. 本发明涉及医药、有机化工及精细化工领域，具体涉及一种由二氧化碳制备含磺酰胺杂环丙烯酸酯的方法。以邻炔基芳基磺酰胺为原料，干燥无水的二甲亚砜(DMSO)做溶剂，碱性条件下，室温反应48小时，然后加入碘甲烷50℃油浴锅反应1小时合成产物。反应经过简单后处理即可以中等至高的产率得