Kit for predicting papillary thyroid carcinoma susceptibility

• Main Authors: GUAN XUHUIZI, YAN AN, ZHU XIAOQUAN, MIAO GANG, ZHAO YANYANG, AMURITA
• Format: Patent
• Language: Chinese; English
• Published: 15.09.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention discloses a kit for predicting papillary thyroid carcinoma susceptibility, and belongs to the technical field of medical biotechnology and medical detection. According to the invention, genomic DNA of a subject is extracted, and the genotype of the position 45271238 of the exon region of the PLK3 gene of the subject is determined, so that the susceptibility of the subject to papillary thyroid carcinoma is predicted. The invention has the following advantages: the correlation between the variation of the 45271238 site of the exon region of the PLK3 gene and papillary thyroid carcinoma is elaborated for the first time, and a method for evaluating the risk of a subject suffering from papillary thyroid carcinoma is provided. The method can be used for risk assessment, screening and early diagnosis of papillary thyroid carcinoma, and has the advantages of noninvasive property, rapidness and high accuracy. 本发明公开了一种预测甲状腺乳头状癌易感性的试剂盒，属于医学生物技术与医学检测技术领域。本发明通过提取受试者的基因组DNA，测定受试者的PLK3基因外显子区45271238位置的基因型，预测受试