Bifunctional antagonist of tumor necrosis factor-alpha and transforming growth factor-beta and application thereof

• Main Authors: HAN HUIQUAN, ZHOU XIAOLAN
• Format: Patent
• Language: Chinese; English
• Published: 12.09.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure provides novel bifunctional antagonistic polypeptides comprising at least one TNF-[alpha] binding domain and at least one TNF-[beta] binding domain, which are very capable of isolating TNF-[alpha] and TNF-[beta] in parallel. Also provided are pharmaceutical compositions of such bifunctional polypeptide antagonists and their use for the treatment of various complex disease conditions, the pathogenesis of which involves the activation of both the TNF-alpha mediated NF-[kappa] B signaling pathway and the TGF-beta mediated Smad2/3 signaling pathway. 本发明公开内容提供了包含至少一个TNF-α结合结构域和至少一个TNF-β结合结构域的新颖的双功能拮抗多肽，其非常能够并行地隔离TNF-α和TNF-β。还提供了这样的双功能多肽拮抗剂的药物组合物及其用于治疗各种复杂疾病状况的用途，这些疾病状况的发病机制涉及激活TNF-α介导的NF-κB信号传导途径和TGF-β介导的Smad2/3信号传导途径两者。