Preparation method of sacubitril calcium

• Main Authors: HUANG LI, ZENG JIANHUA, LIAO JUN, YANG SHENKUN, WU DEQI, MA WENJING, CHANG YONGJIE, FENG LEI, ZOU JINSHUANG
• Format: Patent
• Language: Chinese; English
• Published: 08.09.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a preparation method of sacubitril calcium. The preparation method comprises the following steps: adding a compound 1 into a pre-prepared mixed solution, carrying out esterification and deprotection reaction, after the esterification and deprotection reaction is finished, carrying out vacuum concentration until the compound 1 is dry, adding a non-polar solvent, carrying out stirring dissolution, then adding succinic anhydride and triethylamine, carrying out acylation reaction, and after the acylation reaction is finished, carrying out vacuum concentration until the compound 1 is dry; sequentially adding water for quenching, acid washing, water washing, standing and collecting an organic layer; and adding an alkali metal weak acid salt aqueous solution into the obtained organic layer to carry out a sodium salt forming reaction, separating the organic layer, adding a co-crystallization solvent into the water layer, dropwise adding a calcium chloride aqueous solution, centrifuging, washin