METHOD FOR PRODUCING AC-225 SOLUTION AND METHOD FOR PRODUCING MEDICINE USING AC-225 SOLUTION

• Main Authors: ITO TAKU, ICHINOSE, JUN, ICHIKAWA HIROAKI, NAGATSU, KOTARO, HONDA YOSHIO, SUZUKI HISASHI, IMAI TOMOYUKI
• Format: Patent
• Language: Chinese; English
• Published: 05.09.2023
• Subjects: CONVERSION OF CHEMICAL ELEMENTS; NUCLEAR ENGINEERING; NUCLEAR PHYSICS; PHYSICS; RADIOACTIVE SOURCES

One embodiment of the present invention relates to a method for producing a 225Ac solution or a method for producing a medicine using the same, the method comprising: a step for irradiating a 226Ra target with particles to generate radioisotopes (Ac) of two or more actinides including at least 225Ac; a step for obtaining a solution (1) containing 226Ra and Ac by dissolving the 226Ra target after the step; a step for separating 226Ra and Ac contained in the solution (1) to obtain a solution (2) having an Ac concentration higher than that of the solution (1); a step in which Ac other than 225Ac contained in the solution (2) is decayed to obtain a solution (3) containing a radium isotope (Ra) obtained by decaying; and a step for separating Ra and Ac contained in the solution (3) to obtain a solution (4) in which the 225Ac concentration is increased compared to the solution (3). The solution (4) is used for producing a medicine containing, as an active ingredient, a complex of an Nd2 antibody or a targeting agent