Preparation and application of oral colon-targeted high-molecular polymer

• Main Authors: KO JONG-HO, HOU YAN, CHEN LIQING, KIM MYEONG-HEE, HUANG WEI, WU HAO
• Format: Patent
• Language: Chinese; English
• Published: 29.08.2023
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention belongs to the field of pharmaceutical preparations, and relates to preparation and application of an oral colon-targeted high-molecular polymer. The invention prepares a hyaluronic acid modified inulin high-molecular polymer which is a functional drug delivery material with oral colon targeting property, and the application research is carried out on the hyaluronic acid modified inulin high-molecular polymer. According to the invention, carboxyl of hyaluronic acid and hydroxyl of inulin are connected by a condensation method, and the prepared novel carrier (HA-IN) is safe and non-toxic, and has good stomach and intestinal stability and good colon targeting ability. After the HA-IN high-molecular polymer is compounded with the drug-loaded micelle, the residence time of an oral drug in a body can be prolonged, the accumulation of colon tumors on the drug is improved, and the anti-tumor curative effect is improved, so that the HA-IN high-molecular polymer has a relatively good development prospect