Paclitaxel derivative injection and application thereof

• Main Authors: TANG HUI, WANG YINGYING, LIU DONGFEI, FAN JIN, FENG GUOBING
• Format: Patent
• Language: Chinese; English
• Published: 29.08.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of medical biology, and discloses a paclitaxel derivative injection and application thereof.The paclitaxel derivative injection is prepared from a paclitaxel derivative, pharmaceutic adjuvants and an aqueous medium, and the paclitaxel equivalent concentration range of the paclitaxel derivative is 1-10 mg/mL; the equivalent weight ratio of the pharmaceutic adjuvant to the paclitaxel derivative is (10-100): 1; a water-soluble paclitaxel derivative is selected as an active ingredient, use of polyoxyethylated castor oil is avoided, the prescription can improve in-vivo pharmacokinetic properties of the paclitaxel derivative, liver and kidney aggregation of the paclitaxel derivative is avoided, adverse reactions are reduced, and compliance and safety of drugs in the clinical use process are improved; the preparation method is convenient and easy to control, the production efficiency is high, and industrial production is easy to realize. The paclitaxel derivative injectio