Roxithromycin nasal in-situ gel as well as preparation method and application thereof

• Main Authors: JI LI, HE YUXIN, WANG CHENG, CUI PENGFEI, ZHOU SHUWEN, WANG JIANHAO, LEI YANPENG
• Format: Patent
• Language: Chinese; English
• Published: 29.08.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to roxithromycin nasal in-situ gel as well as a preparation method and application thereof, and roxithromycin is directly delivered to a nasal cavity in a local administration manner by taking temperature-sensitive in-situ gel as a carrier. And the temperature-sensitive type in-situ gel is prepared from poloxamer 188 and poloxamer 407. Pharmacokinetic experiments show that the relative bioavailability AUC of an in-situ gel group is about 5 times that of an oral group, and the roxithromycin nasal in-situ gel can significantly improve the drug concentration of blood and the drug bioavailability. The roxithromycin nasal in-situ gel provided by the invention is a novel preparation with application potential. 本发明属于药物制剂技术领域，具体涉及一种罗红霉素鼻用原位凝胶及其制备方法与应用，以温敏型原位凝胶作为载体通过局部给药的方式将罗红霉素直接递送到鼻腔。温敏型原位凝胶是由泊洛沙姆188、泊洛沙姆407组成。通过药动学实验可知，原位凝胶组相对生物利用度AUC是口服组的5倍左右，罗红霉素鼻用原位凝胶可以显著提高血液的药物浓度，以及药物的生物利用度。本发明所涉及的罗红霉素鼻用原位凝胶是一种具有应用潜力的新制剂。