Methods and kits for diagnosing covid-19 disease

• Main Author: PRETORIUS, ETHERICIA
• Format: Patent
• Language: Chinese; English
• Published: 25.08.2023
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The present invention relates to a method for detecting persistent abnormal (amyloid) clots in a sample using a fluorescence or microscopy detection method for diagnosing COVID-19 disease, preferably acute post-COVID-19 syndrome, in a subject, wherein the presence of persistently abnormal (or amyloid) clots, in particular clots that are resistant to fibrin hydrolysis, in the sample is indicative of acute COVID-19 disease or acute post-COVID-19 syndrome in the subject. The invention also relates to a diagnostic kit for diagnosing acute COVID-19 disease, in particular acute post-COVID-19 syndrome, in a subject based on the disclosed method. 本发明涉及使用荧光或显微术检测方法检测样品中的持续异常(淀粉样)凝块以在对象中诊断COVID-19疾病(优选急性COVID-19后综合征)的方法，其中所述样品中持续异常(或淀粉样)凝块(特别是对纤维蛋白水解具有抗性之凝块)的存在是所述对象中急性COVID-19疾病或急性COVID-19后综合征的指示。本发明还涉及用于基于所公开的方法在对象中诊断急性COVID-19疾病(特别是急性COVID-19后综合征)的诊断试剂盒。