In-vitro method for recovering tumor cells in blood in removal operation

The present invention relates to an ex vivo method for removing tumor cells from intraoperative recovered blood, the method comprising contacting a tri-functional antibody with said blood to form an aggregate or conjugate of antibodies, tumor cells and immune cells, centrifuging to obtain a red bloo...

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Bibliographic Details
Main Authors LINDHOFER HANNES, HEISE MICHAEL, BRACHT FRANK
Format Patent
LanguageChinese
English
Published 22.08.2023
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to an ex vivo method for removing tumor cells from intraoperative recovered blood, the method comprising contacting a tri-functional antibody with said blood to form an aggregate or conjugate of antibodies, tumor cells and immune cells, centrifuging to obtain a red blood cell concentrate, and filtering to remove the aggregates or conjugates and residual antibodies from the red blood cell concentrate. 本发明涉及一种从术中回收血液中去除肿瘤细胞的离体方法，该方法包括将三功能抗体与所述血液接触以形成抗体、肿瘤细胞和免疫细胞的聚集体或结合物，离心以获得红细胞浓缩物，以及过滤以从所述红细胞浓缩物中除去所述聚集体或结合物和残留抗体。
Bibliography:Application Number: CN202180086311