Preparation method of 2, 3-dimethyl-4-nitrobenzoic acid

• Main Authors: ZHAO WANSHENG, WANG BOWEN, WEN BIN, NAN PEIRAN, CHEN XINGQUAN
• Format: Patent
• Language: Chinese; English
• Published: 22.08.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a preparation method of 2, 3-dimethyl-4-nitrobenzoic acid, which is characterized in that 2, 3-dimethylaniline is used as a raw material, and the 2, 3-dimethyl-4-nitrobenzoic acid is synthesized through protective nitrification, deprotection, diazo bromination, nitrification, amidation and acidification reaction, the 2, 3-dimethyl-4-nitrobenzoic acid is prepared by adopting the method, on the premise of ensuring the yield, the yield of the 2, 3-dimethyl-4-nitrobenzoic acid is increased, and the yield of the 2, 3-dimethyl-4-nitrobenzoic acid is increased. The whole steps are simple to operate, the preparation is easy, side reactions are few, and the post-treatment steps of the product are simple. 一种2,3-二甲基-4-硝基苯甲酸的制备方法，是以2,3-二甲基苯胺为原料，经保护硝化、脱保护、重氮上溴、腈化、酰胺化以及酸化反应合成2,3-二甲基-4-硝基苯甲酸，采用上述方法制备2,3-二甲基-4-硝基苯甲酸，在保证产率的前提下，整体步骤操作简单，易于制作，副反应少，且产品的后处理步骤简单。