Dual-responsiveness multi-block polymer, synthesis method and application of biodegradable polymer micelle and anti-cancer drug carrier

• Main Authors: WANG CHENFEI, SUN SHUAIWEI, ZHOU DEZHONG
• Format: Patent
• Language: Chinese; English
• Published: 08.08.2023
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention discloses a dual-responsiveness multi-block polymer, a synthesis method and application of biodegradable polymer micelles and anti-cancer drug carriers, and belongs to the field of biomedical macromolecules, PPS60-SS-b-mPEG disclosed by the invention has dual responsiveness and high biocompatibility, can form drug-loaded nano-micelles with excellent drug loading ratio and encapsulation efficiency with anti-cancer drugs, and can be used for preparing the anti-cancer drugs. The responsive drug-loaded nano-micelle based on the multifunctional polymer has specific toxicity to tumor cells, has small toxic and side effects, has better performance than responsive liposomes and responsive inorganic nanoparticles as a multi-response carrier of anti-cancer drugs, and has huge application potential in the field of cancer treatment. 本发明公开了一种双响应性多嵌段聚合物、合成方法及可生物降解聚合物胶束和抗癌药物载体应用，属于生物医用高分子领域，本发明公开的PPS60-SS-b-mPEG具有双重响应性，生物相容性高，能与抗癌药物形成优异载药率和包封率的载药纳米胶束，对肿瘤细胞有特异性毒性，毒副作用小，作为抗癌药物的多响应载体，其性能优于响应性脂质体和响应性无机纳米粒子，这种基于多功能