MUC1 BINDING MOLECULES AND USES THEREOF

• Main Authors: QIAN QIJUN, ZHU WEIMIN, CAI XIANGHAI, SUN YAN
• Format: Patent
• Language: Chinese; English
• Published: 08.08.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention relates to an MUC1 binding molecule and application thereof, and particularly provides the MUC1 binding molecule, the MUC1 binding molecule comprises an anti-MUC1 single-domain antibody, a complementary determining region (CDR) of the single-domain antibody comprises CDR1, CDR2 and CDR3, the CDR1 comprises a sequence as shown in SEQ ID NO: 1, the CDR2 comprises a sequence as shown in SEQ ID NO: 2, and the CDR3 comprises a sequence as shown in SEQ ID NO: 3. The MUC1 binding molecule can be bound with MUC1 with high specificity, and has relatively high affinity and biological activity. 本发明涉及MUC1结合分子及其应用，具体提供一种MUC1结合分子，包含抗MUC1单域抗体，所述单域抗体的互补决定区CDR包含CDR1、CDR2和CDR3，其中CDR1包括SEQ ID NO:1所示的序列、CDR2包括SEQ ID NO:2所示的序列、和CDR3包括SEQ ID NO:3所示的序列。所述MUC1结合分子能够高特异性地结合MUC1，具有较高的亲和力和生物活性。