Application of miR-5120

• Main Authors: ZHANG KEQIN, ZONG GUANNAN, HU KERONG, KONG DEHONG, FANG PING, YE ZHENGQIN, LI RAN, XUE YING, XU WEI, LIU GUANGHUI
• Format: Patent
• Language: Chinese; English
• Published: 08.08.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to an application of miR-5120 (miR-5120). The invention provides application of a reagent for inducing the expression of miR-5120 in preparation of a reagent for inhibiting the expression of an alpha/beta hydrolase domain 6. According to the present invention, the miR-5120 and the target gene alpha/beta hydrolase structural domain 6 (ABHD6) participate in the incidence of the metabolism-related fatty liver disease (MAFLD), and can be adopted as the MAFLD drug treatment target; 本发明涉及一种miR-5120的应用；提供诱导miR-5120表达的试剂在制备抑制α/β水解酶结构域-6表达的试剂中的应用；本发明的miR-5120及靶基因α/β水解酶结构域-6(ABHD6)参与了代谢相关性脂肪性肝病(MAFLD)的发病，并可以作为MAFLD的药物治疗靶点。