Preparation and anti-tumor application of targeted delivery AIEgen for radiotherapy enhancement immunotherapy carrier

• Main Authors: CHEN MEILI, LI XIANMING, DUO YANHONG, LI ZIHUANG, LUO GUANGHONG
• Format: Patent
• Language: Chinese; English
• Published: 08.08.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses preparation of a carrier for enhancing immunotherapy by targeted delivery of AIEgen for radiotherapy and an anti-tumor application. The invention relates to the technical field of biology, in particular to preparation of a carrier for enhancing immunotherapy by targeted delivery of AIEgen for radiotherapy and anti-tumor application. The invention provides a medicine capable of inhibiting the activity of tumor cells or resisting tumor activity, the active ingredient of the medicine contains VNP (at) TBTP-Au, and the VNP (at) TBTP-Au is composed of active bacteria and TBTP-Au loaded by an active bacteria carrier. The attenuated salmonella VNP20009 is used as a newly synthesized TBTP-Au radiosensitizer transfer carrier, and the immunostimulation effect of the attenuated salmonella VNP20009 is combined, so that tumor radioimmunotherapy is realized, a new strategy is provided for the organic combination of bacteria and image-guided radiotherapy, and a foundation is laid for the combination