Preparation method of reversed-phase temperature-sensitive hydrogel printing ink

• Main Authors: MIAO HONGYUE, SHI BAOZHANG, XU LIPING, ZHANG HUA
• Format: Patent
• Language: Chinese; English
• Published: 04.08.2023
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS; GENERAL PROCESSES OF COMPOUNDING; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

The invention discloses a preparation method of reversed-phase temperature-sensitive hydrogel printing ink, which comprises the following steps: compounding methylacryloylated gelatin (GelMA) and F127 dialkyl acrylate (F127DA) with reversed-phase temperature-sensitive characteristics in a sodium alginate matrix, synergistically utilizing the physical action and covalent action between molecules, covalently crosslinking temperature-sensitive components to form a body gel, and preparing the reversed-phase temperature-sensitive hydrogel printing ink. And converting into microgel to obtain the reverse-phase temperature-sensitive hydrogel printing ink with the total solid content of less than 8% and adjustable degradation and modulus. The hydrogel printing ink has the advantages of low concentration and low temperature sensitivity, overcomes the problems caused by high concentration and high temperature sensitivity of the existing hydrogel printing ink, and can promote biological printing and clinical conversion o