Indole alkaloid compound and preparation method thereof

• Main Authors: YANG JIAXI, XIAO XIAOWU, LIN KAIPENG, WANG JIE, ZHOU ZHIQIANG, WU MINYU, FU HUIZHENG
• Format: Patent
• Language: Chinese; English
• Published: 01.08.2023
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The invention relates to the technical field of traditional Chinese medicine extraction and separation, phytochemistry and medicine, in particular to an indole alkaloid compound and a preparation method thereof. The invention provides a novel compound extracted from rhizoma typhonii flagelliformis. Dry rhizoma typhonii flagelliformis is used as a raw material, and the novel indole alkaloid compound is obtained through the steps of decoction with water, vacuum concentration, extraction, reversed-phase C18 chromatographic separation and the like. The extraction and separation process is simple to operate, easy to control and suitable for industrial production; the obtained indole alkaloid compound has anti-proliferative activity and anti-tumor effect, and has a good application prospect in preparation of drugs for treating gastric cancer or liver cancer. 本发明涉及中药提取分离、植物化学及医药技术领域，具体涉及一种吲哚生物碱化合物及其制备方法。本发明提供了从水半夏中提取的一种新化合物：以干燥的水半夏为原料，通过加水煎煮、减压浓缩、萃取、反相C18色谱分离等步骤得到一种新的吲哚生物碱化合物。本发明提取分离工艺操作简单、易于控制，适合工业化生产；所得吲哚生物碱化合物具有抗