Adsorbent for improving anticoagulation effect and preparation method and application thereof

• Main Authors: BAI KE, LIU QUNQI
• Format: Patent
• Language: Chinese; English
• Published: 01.08.2023
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; SEPARATION; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention relates to an adsorbent for improving anticoagulation effect, the adsorbent comprises a carrier and a biomimetic material modified on the carrier, the carrier is a styrene-divinylbenzene cross-linked porous polymer, and the biomimetic material is a hydroxyl and/or carboxyl-containing 3-hydroxyl bicyclo [3, 3, 0] heptane derivative. According to the invention, an anti-coagulation mode different from an existing conventional anti-coagulation mode is adopted, the surface of a polymer carrier is chemically modified with a group beneficial to reducing platelet aggregation, and coating treatment on the surface of the carrier is not needed, so that the adsorbent which has a good anti-coagulation effect and is used in the field of blood purification is obtained. 本发明涉及一种提高抗凝血效果的吸附剂，包括载体和修饰在载体上的仿生材料，载体为苯乙烯-二乙烯苯交联的多孔聚合物，仿生材料为含有羟基和/或羧基的3-羟基二环[3、3、0]庚烷的衍生物。本发明采用不同于现有常规的抗凝方式，通过将有利于减少血小板聚集的基团化学修饰于聚合物载体表面，无需对载体表面包膜处理，从而获得一种抗凝效果良好的用于血液净化领域的吸附剂。