Use of diaminoheterocyclic carboxamide compounds

• Main Authors: EGUCHI TOMOHIRO, YAMAKI YOKO, MORI MASAMICHI
• Format: Patent
• Language: Chinese; English
• Published: 01.08.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides the use of 6-ethyl-3-({3-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] phenyl} amino)-5-(tetrahydro-2H-pyran-4-ylamino) pyrazine-2-carboxamide, or a pharmaceutically acceptable salt thereof, in the manufacture of a pharmaceutical composition for the treatment of a subject suffering from a cancer associated with AXL, wherein the cancer associated with the AXL is a cancer that gains resistance to the treatment with the anti-cancer drug due to activation of the AXL. 本发明提供6-乙基-3-({3-甲氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-基]苯基}氨基)-5-(四氢-2H-吡喃-4-基氨基)吡嗪-2-甲酰胺或其药学上可接受的盐在制造用于治疗患有与AXL相关的癌的对象的医药组合物中的用途，其中与AXL相关的癌为因AXL活化而获得对抗癌药物治疗的抗药性的癌。