Oligonucleotide compositions and methods thereof

• Main Authors: YANG HAILIN, PARK TOM LIANTANG, VARGHESE CHANDRA, PRASHANT. MONIAN, YU HUI, KANDASAMUTHU. KANDASAMUTHU, LU GENLIANG, CHIKDU SHAKTI SHIVALILA, HERSH ANDREW GUZIO, GODFREY JACK DAVID, BLAY DAVID JOHN, LAMARTINA ANTHONY, DESAI JIGAR, SHIMIZU MAMORU, STANDLEY STEFANIE MICHELLE, KUMARASAMY JAYAKANTHAN, APOLONI LUCIANO ENRIQUE, IWAMOTO NAOKI, BUTLER DAVID CHARLES DONNELL, MALAPPAN SUBRAMANIAN
• Format: Patent
• Language: Chinese; English
• Published: 28.07.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

In particular, the disclosure provides oligonucleotides and compositions thereof. In some embodiments, the provided oligonucleotides and compositions can be used for adenosine modification. In some embodiments, the disclosure provides methods for treating various conditions, disorders, or diseases that can benefit from adenosine modification. 尤其是，本披露提供了寡核苷酸及其组合物。在一些实施例中，所提供的寡核苷酸和组合物可用于腺苷修饰。在一些实施例中，本披露提供了用于治疗可受益于腺苷修饰的多种病症、障碍或疾病的方法。