Carbazole derivative-metal oxide nanoparticles as well as preparation method and application thereof

• Main Authors: GAO WEIWEI, YANG XIAOCHAN, ZHANG YUJIAO, PANG XUEYAO, TAN JIAJUN, WANG WENHUI, SONG SHENGNAN, DING YONG, LI BO
• Format: Patent
• Language: Chinese; English
• Published: 28.07.2023
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; NANOTECHNOLOGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention discloses a preparation method of carbazole derivative-metal oxide nanoparticles, which comprises the following steps: 1) mixing and stirring a carbazole derivative and a metal salt according to different proportions until the carbazole derivative and the metal salt are uniformly dispersed in a polar solvent to obtain a dispersion liquid; 2) transferring the dispersion liquid into a reaction kettle, and reacting at 150-250 DEG C for 2-20 hours; and 3) after the reaction is finished, centrifuging, cleaning and drying to obtain the carbazole derivative-metal oxide nanoparticles. The carbazole derivative-metal oxide nanoparticles are obtained by coordinating and assembling the carbazole derivative containing the antibacterial fragment and the metal oxide, and the carbazole derivative-metal oxide nanoparticles can be used for synergistically sterilizing through chemical power-photo-thermal dual effects, so that the antibacterial efficiency is greatly improved. According to the method, the reaction c