Deuterated acrylamide JAK3 inhibitor drug and application

The invention provides the deuterated compound of the deuterated acrylamide JAK3 inhibitor and the pharmaceutically acceptable salt thereof, so that the inhibition activity on JAK3 enzyme is remarkably improved, the pharmacokinetic property of the JAK3 inhibitor is further improved, and the administ...

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Bibliographic Details
Main Author LIU CHUNHE
Format Patent
LanguageChinese
English
Published 28.07.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides the deuterated compound of the deuterated acrylamide JAK3 inhibitor and the pharmaceutically acceptable salt thereof, so that the inhibition activity on JAK3 enzyme is remarkably improved, the pharmacokinetic property of the JAK3 inhibitor is further improved, and the administration dosage and possible toxic and side effects are reduced. The invention relates to a deuterated acrylamide compound of a JAK3 inhibitor, which is shown in the following formula I, wherein the structure of the deuterated acrylamide compound is shown in the specification. 本发明提供了氘代丙烯酰胺类JAK3抑制剂的氘代化合物及其药学上可接受的盐，显著提高了对JAK3酶的抑制活性，进一步改善JAK3抑制剂的药代动力学性质，降低给药剂量和可能的毒副作用。本发明所述一种如下式Ⅰ所示的JAK3抑制剂的氘代丙烯酰胺类化合物，其结构如下：。
Bibliography:Application Number: CN202310745179