Method for preparing spiro compound

• Main Authors: WU ZHIXUAN, XIAO ZIYAN, YI RONGNAN, CHEN WEIXU, YI XUANYU, SUN GAOFEI, CHEN YAOQING, CHEN JUNHAO, HUANG JUANJUAN, ZHAO MINGMING
• Format: Patent
• Language: Chinese; English
• Published: 25.07.2023
• Subjects: APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a method for preparing a spiro compound, which comprises the following steps: mixing a 1, 7-eneyne compound, an oxime ester compound, a maleimide compound, a copper catalyst and a solvent under a protective atmosphere or vacuum condition, and reacting to obtain a heteropolycyclic compound; wherein the copper catalyst is one or more of cuprous iodide, cuprous oxide, cuprous chloride, cuprous bromide, copper trifluoromethanesulfonate and copper sulfate. According to the method disclosed by the invention, the copper salt which is low in price and easy to obtain is used as an accelerant, a noble metal catalyst and a ligand are not needed, and the spiro derivative is constructed by simultaneously constructing four C-C bonds and one C = N bond in one pot, so that the method has the advantages of wide application range of reaction substrates, simple and mild conditions, relatively high atom economy and the like; good industrial application prospects are realized. 本发明涉及一种制备螺环化合物的方法，在保护气氛或真空条件