Donepezil derivative as well as preparation method and application thereof

• Main Authors: ZHAI JINGFANG, HAO CANHUA, LIU TENG, ZHOU MIN, WANG XIAOJING, LIU REN, SUN JIE, PAN YINBO, SHI ZEZHOU
• Format: Patent
• Language: Chinese; English
• Published: 25.07.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a donepezil derivative as shown in a structural formula (I) as well as a preparation method and application of the donepezil derivative. Compared with the prior art, the donepezil derivative shown in the formula (I) has the effect of relieving the Alzheimer's disease, plays a role in various ways of inhibiting acetylcholin esterase, butyrylcholine esterase, beta-amyloid protein and the like, can be used as a medicine for treating the Alzheimer's disease in a multi-target manner, and has good popularization and application values. 本发明公开了一种结构式(I)所示的多奈哌齐衍生物、其制备方法及其应用。与现有技术相比，式(I)所示多奈哌齐衍生物具有缓解阿尔兹海默病的作用，通过抑制乙酰胆碱酯酶、丁酰胆碱酯酶、抑制β-淀粉样蛋白等多种途径发挥作用，可以作为多靶点治疗阿尔兹海默病的药物，具有很好的推广应用价值。