2, 5-disubstituted and 2, 5, 6-trisubstituted 3-methylpyrazines as allosteric SHP2 inhibitors

The present application relates to SHP2 inhibitors and their use for the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same. 本申请涉及SHP2抑制剂及其用于治疗疾病的用途。还公开的是包含其的药物组合物。

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Bibliographic Details
Main Authors BUCKL ANDREAS, GIL AMIT, KISS GYORGY, WON WALTER, KOLTUN ELENA S, JOGALEKAR AMOL, SEMKO CHRISTOPHER, AAY NAING, MELLEM KEVIN
Format Patent
LanguageChinese
English
Published 25.07.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present application relates to SHP2 inhibitors and their use for the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same. 本申请涉及SHP2抑制剂及其用于治疗疾病的用途。还公开的是包含其的药物组合物。
Bibliography:Application Number: CN202310268752