Application of narcotine Noscapine in promotion of spinal cord injury repair

• Main Authors: ZHAO YANNAN, DAI JIANWU, MENG WENXIANG, LIN RUIFAN, CHEN BING, XU HONGLIN, YANG LAMEI, LIN CHUNNUAN
• Format: Patent
• Language: Chinese; English
• Published: 25.07.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an application of narcotine Noscapine in promotion of spinal cord injury repair. The repairing effect is evaluated through multiple methods such as behavioral scoring, electrophysiological detection, immunofluorescent staining and computed tomography imaging, and it is found that narcotine Noscapine can improve the conditions of tissue edema and bleeding after injury, laminin deposition at the center of injury is reduced, and the repairing effect of narcotine Noscapine is improved. A three-dimensional imaging result obtained by high-resolution computed tomography shows that the nerve fiber signal of the injury center is obviously enhanced. Therefore, the narcotine Noscapine can promote the recovery of the motor function after the spinal cord injury, and the effect of the narcotine Noscapine is more obvious than that of the taxane medicine Taxol. The method has an important application value. 本发明公开了那可丁Noscapine在促进脊髓损伤修复中的应用。本发明通过行为学评分、电生理检测、免疫荧光染色、计算机断层扫描成像等多种方法评估修复效果，发现那可丁Noscapine能够改善