Live strain of staphylococcus aureus and application thereof

• Main Authors: DENG JIAN, ZHANG BAOZHONG, YUEN KWOK-YUNG, HUANG JIANDONG, ZHU XUAN
• Format: Patent
• Language: Chinese; English
• Published: 21.07.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention relates to the field of biomedicine. In particular, the invention relates to a live strain of staphylococcus aureus and application thereof. More specifically, the present invention relates to a live strain of Staphylococcus aureus lacking adenosine synthase A (AdsA) activity, a vaccine against Staphylococcus aureus infection comprising said live strain, and a method of preventing and/or treating Staphylococcus aureus infection in a subject by administering said live strain. 本发明涉及生物医学领域。特别地，本发明涉及一种金黄色葡萄球菌的活菌株及其用途。更具体地，本发明涉及缺乏腺苷合酶A(AdsA)活性的金黄色葡萄球菌活菌株，包含所述活菌株的抗金黄色葡萄球菌感染的疫苗，以及通过施用所述活菌株预防和/或治疗对象的金黄色葡萄球菌感染的方法。