Complex comprising water-soluble beta blocker and lecithin

• Main Authors: MONMA SOUICHI, ISHII ITSUKO
• Format: Patent
• Language: Chinese; English
• Published: 21.07.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention addresses the problem of providing an external pharmaceutical composition imparting an excellent balance of light stability, transdermal absorbability, and skin retention to a beta blocker (particularly propranolol hydrochloride), and provides a complex comprising a water-soluble beta blocker and lecithin, a method for producing the complex, an external pharmaceutical composition containing the complex, and the like. When the complex or an oil-in-oil dispersion containing the complex is applied to a conventional pharmaceutical external preparation prescription (for example, a W/O type cream), the complex containing a beta blocker is caused to be present in the O phase, thereby avoiding contact with water and dissolved oxygen and reducing the risk of photolysis. 本发明的课题为提供对β阻断剂(特别是普萘洛尔盐酸盐)赋予光稳定性，经皮吸收性及皮肤滞留性的平衡优异的外用医药组合物，提供由水溶性β阻断剂及卵磷脂形成的复合体、制造该复合体的方法、包含该复合体的外用医药组合物等。将该复合体、或包含该复合体的油中分散液应用于现有的医药外用剂处方(例如，W/O型的霜)，通过使包含β阻断剂的复合体存在于O相，从而避免与水、溶解氧的接触，降低光分解的风险。