Method for synthesizing delta-methyl ketone by one-pot method

The invention discloses a method for synthesizing delta-methyl ketone by a one-pot method, which specifically comprises the following steps of: carrying out Saucy-Marbet rearrangement reaction on allyl alcohol or propargyl alcohol and 2-alkoxy propylene by the one-pot method under the combined actio...

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Bibliographic Details
Main Authors HUANG WENXUE, SHEN WEN, LI YUAN, SUN YUANYUAN, JIA ZHENGRUI, MA PENGCHENG, JANG YOUNG-JIN, YANG RUI
Format Patent
LanguageChinese
English
Published 21.07.2023
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a method for synthesizing delta-methyl ketone by a one-pot method, which specifically comprises the following steps of: carrying out Saucy-Marbet rearrangement reaction on allyl alcohol or propargyl alcohol and 2-alkoxy propylene by the one-pot method under the combined action of an acid catalyst and a hydrogenation catalyst, and carrying out hydrogenation reaction after the reaction is finished, so as to obtain a delta-methyl ketone product. The method has the main advantages that the allylic alcohol or propargyl alcohol is converted into the delta-methyl ketone through the one-pot method, and compared with the existing technological process, separation and purification of rearrangement products are omitted, so that the technological process is more simplified and efficient. Secondly, after the rearrangement reaction is finished, the special organic base is adopted to neutralize the acid catalyst, so that the keto-carbonyl group of the product delta-methyl ketone is prevented from bei
Bibliography:Application Number: CN202310402988