Application of fisetin in preparation of salmonella type III secretion system inhibitor

• Main Authors: DENG XUMING, LI SIQI, FENG HAIHUA, WANG JIANFENG, LIU HONGTAO, QIU JIAZHANG
• Format: Patent
• Language: Chinese; English
• Published: 21.07.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to an application of fisetin in preparation of a salmonella type III secretion system inhibitor and an anti-salmonella infection drug, and the fisetin is prepared by taking a human epidermoid cell cervical cancer cell line (HeLa) as an infection carrier; a cell injury protection test and a mouse salmonella infection treatment test prove that fisetin has a remarkable inhibition effect on salmonella infection by influencing the function of a salmonella type III secretion system. Compared with the traditional antibiotics, the traditional Chinese medicine active compound fisetin can play an anti-infection role by targeted inhibition of the function of a salmonella type III secretion system, gives smaller survival pressure to bacteria, is not easy to induce the generation of drug resistance, and has the characteristics of wide source, low cost and high cure rate. 本发明涉及漆黄素在制备沙门氏菌Ⅲ型分泌系统抑制剂及抗沙门氏菌感染药物中的应用，以上皮样细胞人宫颈癌细胞系(HeLa)为感染载体，通过细胞损伤保护试验及小鼠沙门氏菌感染治疗试验证实漆黄素通过影响沙门氏菌Ⅲ型分泌系统的功能对沙门氏菌感染具有显著的抑制作用。相比传统抗