Bicyclic reaction method of 1, 6-enyne compound and sulfonyl hydrazide and heteropolycyclic compound

The invention relates to a bicyclic reaction method of a 1, 6-enyne compound and sulfonyl hydrazide, which comprises the following steps: mixing the 1, 6-enyne compound, sulfonyl hydrazide, a catalyst and an oxidant with water, and reacting to obtain a heteropolycyclic compound; wherein the catalyst...

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Main Authors HU YUEFENG, YI RONGNAN, PENG JINYU, YI XUANYU, YANG YUSONG, CHEN YAOQING, CHEN JUNHAO, YANG YONGCAN, HUANG JUANJUAN
Format Patent
LanguageChinese
English
Published 18.07.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a bicyclic reaction method of a 1, 6-enyne compound and sulfonyl hydrazide, which comprises the following steps: mixing the 1, 6-enyne compound, sulfonyl hydrazide, a catalyst and an oxidant with water, and reacting to obtain a heteropolycyclic compound; wherein the catalyst is one or more of tetrabutylammonium iodide, iodine, N-iodosuccinimide, potassium iodide and ammonium iodide; the oxidizing agent is one or more of tert-butyl hydroperoxide, tert-butyl peroxybenzoate, dibenzoyl peroxide and di-tert-butyl peroxide. According to the method, the bicyclic reaction of 1, 6-eneyne and sulfonyl hydrazide can be realized in a water phase, the reaction condition of the method is mild, water is used as a reaction solvent, no organic solvent is needed, two new rings are constructed through one-pot reaction, and the method has the advantages of wide application range of a reaction substrate, greenness and high efficiency, and is particularly suitable for industrial production. 本发明涉及一种1,6-烯炔类化
Bibliography:Application Number: CN202310455168