Synthesis method of 4-iodine-2-methylaniline

The invention relates to a synthetic method of 4-iodine-2-methylaniline as shown in a formula (1). The method comprises the following step: in an aqueous solution, in the presence of potassium iodide, elemental iodine and iodic acid, performing iodination reaction on 2-methylaniline at C-4 site to s...

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Bibliographic Details
Main Authors SHEN WEIYI, JIANG WENTAO, WANG ZHE, NIAN SIYUN, LUO DONGPING
Format Patent
LanguageChinese
English
Published 18.07.2023
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a synthetic method of 4-iodine-2-methylaniline as shown in a formula (1). The method comprises the following step: in an aqueous solution, in the presence of potassium iodide, elemental iodine and iodic acid, performing iodination reaction on 2-methylaniline at C-4 site to synthesize the 4-iodine-2-methylaniline compound. The method has the advantages of high selectivity, simple post-treatment and high product yield and purity, develops a new synthesis route and method for synthesizing 4-iodine-2-methylaniline, and has good application potential and research value. 本发明涉及一种式(1)所示的4-碘-2-甲基苯胺的合成方法。所述方法包括在水溶液中，于碘化钾、单质碘、碘酸存在下，使2-甲基苯胺在C-4位发生碘代反应而合成得到所述4-碘-2-甲基苯胺化合物。所述方法选择性高、后处理简单、产物的产率和纯度高，为合成4-碘-2-甲基苯胺开拓了新的合成路线和方法，具有良好的应用潜力和研究价值。
Bibliography:Application Number: CN202210016783