Cell localization features and immunotherapy

• Main Authors: WOYCHIK JOANNA B, TRILLO-TINOCCO JOHN, COHN DANIEL N, LI GUOQING C, PANDYA DIMPLE, ELIE SIEGFRIED, BASSI VIKRAM A, GRAY FRASER, FISCHER ANTON, CHAN BRYAN JOHN, EDWARDS RICHARD
• Format: Patent
• Language: Chinese; English
• Published: 14.07.2023
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The present disclosure provides a method of identifying a subject suitable for anti-PD-1/PD-L1 antagonist therapy, the method comprising measuring CD8 localization and PD-L1 expression in a tumor sample obtained from the subject. In some aspects, the method further comprises administering to a subje...