Cell localization features and immunotherapy

• Main Authors: WOYCHIK JOANNA B, TRILLO-TINOCCO JOHN, COHN DANIEL N, LI GUOQING C, PANDYA DIMPLE, ELIE SIEGFRIED, BASSI VIKRAM A, GRAY FRASER, FISCHER ANTON, CHAN BRYAN JOHN, EDWARDS RICHARD
• Format: Patent
• Language: Chinese; English
• Published: 14.07.2023
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The present disclosure provides a method of identifying a subject suitable for anti-PD-1/PD-L1 antagonist therapy, the method comprising measuring CD8 localization and PD-L1 expression in a tumor sample obtained from the subject. In some aspects, the method further comprises administering to a subject identified as having a tumor exhibiting an exempt CD8-localized phenotype (i) an anti-PD-1/PD-L1 antagonist therapy or (ii) a combination therapy of an anti-PD-1/PD-L1 antagonist and an anti-CTLA-4 antagonist, where the tumor is PD-L1 negative. 本公开文本提供了鉴定适合于抗PD-1/PD-L1拮抗剂疗法的受试者的方法，所述方法包括测量测定从所述受试者获得的肿瘤样品中的CD8定位和PD-L1表达。在一些方面，方法还包括向被鉴定为患有展现出豁免型CD8定位表型的肿瘤的受试者施用(i)抗PD-1/PD-L1拮抗剂疗法或(ii)抗PD-1/PD-L1拮抗剂与抗CTLA-4拮抗剂组合疗法，其中所述肿瘤呈PD-L1阴性。