Cell localization features and immunotherapy
The present disclosure provides a method of identifying a subject suitable for anti-PD-1/PD-L1 antagonist therapy, the method comprising measuring CD8 localization and PD-L1 expression in a tumor sample obtained from the subject. In some aspects, the method further comprises administering to a subje...
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Main Authors | , , , , , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
14.07.2023
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Abstract | The present disclosure provides a method of identifying a subject suitable for anti-PD-1/PD-L1 antagonist therapy, the method comprising measuring CD8 localization and PD-L1 expression in a tumor sample obtained from the subject. In some aspects, the method further comprises administering to a subject identified as having a tumor exhibiting an exempt CD8-localized phenotype (i) an anti-PD-1/PD-L1 antagonist therapy or (ii) a combination therapy of an anti-PD-1/PD-L1 antagonist and an anti-CTLA-4 antagonist, where the tumor is PD-L1 negative.
本公开文本提供了鉴定适合于抗PD-1/PD-L1拮抗剂疗法的受试者的方法,所述方法包括测量测定从所述受试者获得的肿瘤样品中的CD8定位和PD-L1表达。在一些方面,方法还包括向被鉴定为患有展现出豁免型CD8定位表型的肿瘤的受试者施用(i)抗PD-1/PD-L1拮抗剂疗法或(ii)抗PD-1/PD-L1拮抗剂与抗CTLA-4拮抗剂组合疗法,其中所述肿瘤呈PD-L1阴性。 |
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AbstractList | The present disclosure provides a method of identifying a subject suitable for anti-PD-1/PD-L1 antagonist therapy, the method comprising measuring CD8 localization and PD-L1 expression in a tumor sample obtained from the subject. In some aspects, the method further comprises administering to a subject identified as having a tumor exhibiting an exempt CD8-localized phenotype (i) an anti-PD-1/PD-L1 antagonist therapy or (ii) a combination therapy of an anti-PD-1/PD-L1 antagonist and an anti-CTLA-4 antagonist, where the tumor is PD-L1 negative.
本公开文本提供了鉴定适合于抗PD-1/PD-L1拮抗剂疗法的受试者的方法,所述方法包括测量测定从所述受试者获得的肿瘤样品中的CD8定位和PD-L1表达。在一些方面,方法还包括向被鉴定为患有展现出豁免型CD8定位表型的肿瘤的受试者施用(i)抗PD-1/PD-L1拮抗剂疗法或(ii)抗PD-1/PD-L1拮抗剂与抗CTLA-4拮抗剂组合疗法,其中所述肿瘤呈PD-L1阴性。 |
Author | GRAY FRASER CHAN BRYAN JOHN ELIE SIEGFRIED WOYCHIK JOANNA B BASSI VIKRAM A EDWARDS RICHARD FISCHER ANTON TRILLO-TINOCCO JOHN COHN DANIEL N LI GUOQING C PANDYA DIMPLE |
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Snippet | The present disclosure provides a method of identifying a subject suitable for anti-PD-1/PD-L1 antagonist therapy, the method comprising measuring CD8... |
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Title | Cell localization features and immunotherapy |
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