Functional fragments for reprogramming, combinations and uses thereof

• Main Authors: LIU YUEGUANG, CHEN RULEI
• Format: Patent
• Language: Chinese; English
• Published: 14.07.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention provides a group of transcription factors and a transcription factor combination which can synergistically promote the transdifferentiation of glial cells and reprogram the glial cells into functional neurons or neuron-like cells, and by promoting the expression of the group of transcription factors in vivo or in vitro, the glial cells can be reprogrammed into functional neurons or neuron-like cells. The transcription factor can be effectively applied to repairing damage of a nervous system by transdifferentiation of glial cells or limiting deterioration of brain tumors derived from glial cells by utilizing the transdifferentiation capability of key transcription factors, and the application of the found transcription factor and the combination thereof in preparation of medicines for treating nervous system diseases. 提供了一组可协同促进胶质细胞转分化，重编程为有功能的神经元或类神经元的转录因子、转录因子组合，通过在体内或体外促进这组转录因子的表达，可有效地应用在胶质细胞转分化修复神经系统损伤或利用关键转录因子转分化能力来限制胶质细胞来源的脑肿瘤恶化，以及所发现的转录因子及其组合在制备神经系统疾病药物中的应用。