NLRP3 inflammasome inhibitor and application thereof

• Main Authors: ZHAO KAI, ZHOU WENHU, LYU BEN
• Format: Patent
• Language: Chinese; English
• Published: 14.07.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides an NLRP3 inflammasome inhibitor, the NLRP3 inflammasome inhibitor is a metal complex diethyl dithiocarbonylamine copper salt, application of the NLRP3 inflammasome inhibitor in preparation of a medicine for treating NLRP3 inflammasome activation diseases is provided, and the invention belongs to the technical field of biological medicine. The NLRP3 inflammasome inhibitor disclosed by the invention can directly inhibit NLRP3 inflammasome assembly to achieve the effect of inhibiting NLRP3 inflammasome activation, so that release of inflammatory factors IL-1beta is reduced, finally, the effect of inhibiting pyroptosis can be achieved, inflammatory storm and organ injury caused by NLRP3 inflammasome activation can be obviously relieved, and the NLRP3 inflammasome inhibitor can be used for preventing and treating NLRP3 inflammasome activation. A brand new choice is provided for preparing the medicine for treating the NLRP3 inflammasome activation diseases. 本发明提供了一种NLRP3炎性小体抑制剂，所述NLRP3炎性小体抑制剂