MEANS AND METHODS FOR MODULATING IMMUNE CELL CONNECTION

• Main Authors: THROSBY MARK, VAN LOO PIETER FOKKO
• Format: Patent
• Language: Chinese; English
• Published: 11.07.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present application relates to means and methods for modulating an immune cell cohesion effect. The present invention relates to a composition comprising a multivalent antibody comprising a first variable domain that binds to a first tumor antigen (TA1), a second variable domain that binds to a second tumor antigen (TA2), and a third variable domain that binds to an immune cell linking antigen (IEA); and wherein the composition further comprises a second binding molecule that binds to TA1 or TA2. The invention also relates to a kit of parts comprising said multivalent antibody and a second binding molecule, and to means and methods for treating cancer comprising administering said multivalent antibody and a second binding molecule to a subject in need thereof. 本申请涉及用于调节免疫细胞衔接效应的手段和方法。本发明涉及一种包含多价抗体的组合物，所述多价抗体包含结合第一肿瘤抗原(TA1)的第一可变域、结合第二肿瘤抗原(TA2)的第二可变域和结合免疫细胞衔接抗原(IEA)的第三可变域；并且其中所述组合物进一步包含结合TA1或TA2的第二结合分子。本发明还涉及一种包含所述多价抗体和第二结合分子的部件的试剂盒，并且涉及用于治疗癌症的手段和方法，包括向有需要的受试者施用所述多价抗体和第二结合分子。